#115 new
Gemini Smith

Structural Features of κλ-body

Reported by Gemini Smith | February 22nd, 2024 @ 08:32 AM

A κλ-body does not undergo any engineering or alteration to maintain the natural structure of human IgG. It can mediate effector activities like complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) since it shares the same Fc region as a regular antibody. Additionally, it shares a hinge region with a traditional antibody, allowing the antigen-binding sites to be flexible and oriented in the best possible way. Additionally, it possesses two distinct light-chain constant domains (CL), which provide the antibody stability and solubility and ease its subsequent processing.

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